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Multi-component analysis of bile acids in natural Calculus bovis and its substitutes by ultrasound-assisted solid-liquid extraction and UPLC-ELSD

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Physical function improvements were limited, with grip strength gains in sIBM, slight gait speed increases in sarcopenia, and improved insulin sensitivity in obesity, but no significant changes in mobility or daily function in most trials

Downregulation or deficiency of pyruvate kinase leads to ATP depletion which in turn affects cell viability as well as accumulation of the glycolytic intermediates (2,3-diphosphoglycerate (2,3-DPG) that eventually leads to impaired glycolytic flux 46