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One 2026 narrative review concluded that GLP-1 receptor agonist therapy is associated with meaningful nutritional deficiencies and that individualized nutritional assessment and lab evaluation may be appropriate, especially in people at higher risk of malnutrition

Limiting alcohol and caffeine intake may also decrease gastrointestinal irritation

Research has indicated that metformin treatment may lead to improvements in hormonal imbalances commonly associated with conditions such as PCOS by enhancing insulin sensitivity and indirectly decreasing biochemical hyperandrogenism

A common pattern is modest initial loss (partly water weight, partly from reduced intake), followed by a slower-looking middle period where fat loss is happening but the scale isn't moving dramatically