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Mutations found in the MRP6 gene are associated with genetic abnormalities of the autosomal inherited connective tissue disorder called pseudoxanthoma elasticum (PXE), which is characterized by the presence of dystrophic elastic fibers in the skin, retina, and large blood vessels, causing the appearance of bags in the skin, loss of vision and calcification of blood vessels [100]

Importantly, the three effect measures correlated strongly with each other, supporting the reliability of the individual measures

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