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It is unclear to what extent the reduction in lean mass is attributable to loss of skeletal muscle mass per se, which comprises only one component of total body lean mass in mice, but the lack of effect on fat mass is consistent with the reported paucity of IGF-1Rs on mature adipocytes

95% CI, 0.77-0.87), and ESKD (HR, 0.61

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57 MULTIFOCAL/DIFFUSE PIGMENTATION Physiologic Pigmentation Physiologic pigmentation is the most common multifocal or diffuse oral mucosal pigmentation (Table 54)