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Patients frequently describe a sensation of their internal battery being permanently stuck at one percent, alongside cognitive dysfunction, muscle weakness, and a persistent "brain fog" that makes concentrating nearly impossible

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Pulsatility is thought to matter for the downstream physiological effects of GH, which is part of why research models favor a short GHRH signal (no-DAC) that reinforces natural pulses over a multi-day DAC signal that raises the baseline more persistently

*Correspondence: Hyunju Kang, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers