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Ethics declarations Ethics approval and consent to participate The local research ethics committee (National Research Ethics ServiceNRES Committee, East of England) approved the study: REC reference 14/EE/0018

Adjustment: After 14 days, the dose was titrated according to the manufacturers guidelines (FDA label) to bring blood testosterone into the normal male range (up to a max of 81 mg/day)

Reconstitution: 3.0 mL per 10 mg vial (~3.33 mg/mL) for accurate unit measurements on standard insulin syringes

This careful titration process is vital to minimize potential side effects like nausea or gastrointestinal discomfort, allowing your body to adjust smoothly while maximizing the therapeutic benefits