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Even though vitamin supplements are sold over the counter, any vitamin supplementation should always be discussed with a physician, says Gary Soffer, MD, a Yale Medicine allergist and immunologist who offers guidance on the safe use of dietary supplements, among other things, within the Integrative Medicine Program at Smilow Cancer Hospital
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However, some patients receiving high-dose B12 supplementation or injections may experience adverse reactions, though these relate to the treatment rather than the elevated levels: Possible reactions to B12 supplementation (particularly injections): Skin reactions, including acneiform eruptions or rashes Pruritus (itching) Injection site reactions (with parenteral administration) Rare hypersensitivity reactions Non-specific symptoms such as headaches, dizziness, or gastrointestinal disturbances have been reported by some patients taking B12 supplements, but causality is not well established in clinical evidence
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