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[2,109] A study has shown that only 25% of gut produced endogenous GLP-1 reaches the portal circulation intact, whereas further cleavage happens in the liver causes an additional 40%50% reduction of intact GLP-1, leading to only 10%15% of those enters the systemic circulation

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The main concern for people with hemophilia when starting a new medication is its potential impact on bleeding and blood clotting