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Similarly, the exposure of human dopaminergic SH- SY5Y cells to rotenone caused the nuclear translocation of nuclear factor B (NF-B) and the activation of caspase-3, suggesting that complex I deficiency induced by rotenone can induce NF-B-mediated apoptosis (Figure 3) [68]

Gannon MC, Nuttall JA, Nuttall FQ

They both act to regulate insulin and appetite, but Ozempic has a more lasting effect

We have gone into detail about Witch Hazel in cosmetic products here (it's astringent, soothing, antioxidant and antibacterial), but the important part to know about the leaves is that they contain much, much less active components than the bark