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Life Sci 272:119241 Hassanein EH, Shalkami A-GS, Khalaf MM, Mohamed WR, Hemeida RA (2019) The impact of Keap1/Nrf2, P38MAPK/NF-B and Bax/Bcl2/caspase-3 signaling pathways in the protective effects of berberine against methotrexate-induced nephrotoxicity