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Androgens, whether in excess (Hyperandrogenism) or in deficiency (Hypoandrogenism), cause oxidative stress by affecting immunological responses, fostering chronic inflammation, causing mitochondrial dysfunction, and causing oxidative damage in reproductive organs, thereby affecting fertility and reproductive health ( Table 1 )

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doi: 10.1007/s10753-013-9616-0 188 AhmedSRiegseckerSBeamerMRahmanABelliniJVBhansaliPet al

In conclusion, our structural and functional analyses provide a large body of novel information for defining the molecular mechanism underlying the activation of c-MET in response to HGF and NK1 and paves the way for the eventual therapeutic intervention of diseases caused by aberrant activation of c-MET