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Published pre-clinical studies have used FOXO4-DRI to demonstrate that selective elimination of senescent cells in aged mouse models can improve a range of tissue function parameters including fitness, fur density, renal function, and liver function establishing the broader research principle that senescent cell burden contributes meaningfully to ageing tissue dysfunction and that its targeted reduction produces measurable functional benefits in experimental models

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Therefore, the present study provides several novel contributions by evaluating the possible antioxidant, anti-inflammatory, antiapoptotic, hepatoprotective, cardioprotective, and neuroprotective effects of supplementation with rutin and aescin, alone and in combination with the commercial drug propylthiouracil, in hyperthyroidism-induced rats

Collectively, these data implicate ferroptosis as the mode of macrophage death driven by H 2 O 2 observed in the current study