In the STEP trials, semaglutide was administered as part of a comprehensive lifestyle intervention that included a reduced-calorie diet (approximately 500 kcal/day deficit based on baseline energy requirements) and a minimum of 150 min of physical activity per week [38,39,40,41,42,43,44,45,46, 78, 97]
Tier 3 (research stratum, $1,0003,000 per patient) : reserved exclusively for clinical trials, refractory presentations, or academic investigations
zonisamide Compounded medications: Found may offer compounded semaglutide for eligible patients who cannot take brand-name GLP-1s
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