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Primary applications: wound healing (closure kinetics, collagen organization, tensile strength), tendon and ligament regeneration (Achilles transection, biomechanical testing), gastroprotection (NSAID protection, mucosal barrier, fistula healing), angiogenesis (HUVEC tube formation, VEGF expression, CAM assays), neuroprotection (gut-brain axis, neuroinflammatory reduction), and inflammation studies (cytokine modulation, ERK1/2 pathway)

Sunil VR, Vayas KN, Cervelli JA, et al

A few reviews summarized the pathophysiological functions of ROS (Sugino, 2005

26 27 Additionally, GLP-1-mediated modulation of pain pathways, particularly via microglial activation in the caudal trigeminal nucleus, may exacerbate central sensitization and worsen headache symptoms