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Despite these findings involving JNK in APAP hepatotoxicity, a recent report in mice with hepatocyte-specific Jnk1 and Jnk2 deletion (Jnk hepa ) questioned the role of JNK in APAP-induced hepatotoxicity (Cubero et al., 2016)

The impact of canagliflozin on the risk of neuropathy events: a post-hoc exploratory analysis of the CREDENCE trial