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The low resolution within the ECD of the exendin-4-bound map precluded confident modelling

Some patients experience temporary mood shifts during dose escalation, while others report improved emotional stability as weight loss reduces inflammation and improves sleep quality

However, neither the innate nor the adaptive immune response is affected by the DPP-4 inhibitors being used clinically (128), and reassuringly, there is no evidence for any increased risk of infections in the pooled safety analyses (119123) or in the CV safety outcome trials (125127), in line with the view that the catalytic activity of DPP-4 is not necessary for the co-stimulatory role of CD26 in T-cell activation