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As this pathway is absent in humans and in human commensal bacteria MTAN is a promising candidate as a target for new drugs

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A researcher in 2026 must choose: work on native peptides (ease of SPPS synthesis, abundant literature) or optimised mimetics (better pharmacokinetics, but complex synthesis, less literature)

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Abstract Periodontitis causes the destruction of tooth-supporting tissues, and current therapies for periodontal regeneration are invasive

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