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2024 May 15;313:124159

Available from: Deanfield J, Verma S, Scirica BM, Kahn SE, Emerson SS, Ryan D et al (2024) Semaglutide and cardiovascular outcomes in patients with obesity and prevalent heart failure: a prespecified analysis of the SELECT trial

Early Phase 2 data suggest meaningful reductions in liver fat fraction, particularly relevant to patients with MASLD or MASH

It also comes with real considerations: a strict morning dosing protocol, somewhat higher rates of nausea and vomiting in trials, and a breastfeeding restriction that does not apply to the injection