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The prespecified selection criteria included: (1) RCTs reporting desired cardiovascular or renal outcomes

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After being stimulated, neurons of the paraventricular nucleus of the hypothalamus release corticotropin-releasing hormone (CRH), which will be transported by hypothalamic-pituitary portal circulation and stimulate pituitary corticotroph cells to cleave proopiomelanocortin (POMC) in adrenocorticotrophic hormone (ACTH) [12]

Copper induces oxidative stress and H 2 O 2 production in HepG2 ATP7B-KO cells After 6 h of CuCl treatment, chosen oxidative stress-related genes were significantly upregulated in HepG2 ATP7B-KO cells, while only HMOX1 showed early induction in HepG2 cells