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Despite these underwhelming results, Novo considered the results to be promising and still expects to submit the drug for regulatory approval towards the end of 2025

According to MHRA guidance, a dose increase to 7.2mg per week can be made after a minimum of 4 weeks on the 2.4mg dose for adult patients with obesity

Glucagon receptor activation is thought to increase energy expenditure and promote fat breakdown (lipolysis), which may help explain the substantial weight loss observed in early-phase trials however, these mechanistic effects have not yet been fully characterised in humans and should be regarded as preliminary findings

(2009) The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/CCdh1