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Osmotic pump implantation On Day 0, all mice were implanted subcutaneously with an Alzet Model 2004 minipump, where the stainless-steel cannula was replaced with PEEK tubing (DURECT Corporation, Cat# 0002496) to allow for further body composition scanning

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GOx-mediated catalysis in acidic microenvironments produces H 2 O 2 and gluconic acid, which further reduces pH to accelerate ZIF-67 decomposition and Na 2 S 2 O 8 release

These utilized the standard X-ray tubes with low X-ray flux, required long exposure times, and were originally limited to the evaluation of the radius of gyration (R g ) for easily purified proteins such as hemoglobin and ovalbumin (Guinier et al., 1955)