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Insulin Sensitivity: Both agents improve insulin sensitivity

Mechanism Comparison in Skin Cell Culture GHK-Cu Mechanisms in Skin Research GHK-Cu's activity in skin cell culture operates through multiple simultaneous mechanisms: Copper-dependent enzyme activation: GHK-Cu delivers bioavailable copper to copper-dependent enzymes including lysyl oxidase (collagen and elastin cross-linking) and superoxide dismutase (antioxidant defense)

Maybe, it could be related with the fact that hepatic acyl-CoA cholesterol acyl transferase must first be stimulated by exogenous cholesterol before a stimulatory effect by L-carnitine can take place 31, 32

2) incretins (glucagon-like peptide-1 [GLP-1] receptor agonists and glucose-dependent insulinotropic peptide [GIP]), which induce weight loss and improve metabolic homeostasis with direct hepatic effects