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Emer Cooke, executive director of the EMA, said: We need to step up actions now industry, regulators, healthcare professionals, patients and the public at large all have a role to play in resolving these shortages and we are appealing to everyone to play their part. In June 2023, the UK government declared a national shortage of GLP-1 RAs for type 2 diabetes mellitus until 2024, attributing the shortages to an increase in demand for these products for licensed and off-label indications

The direct beneficiaries fall into two categories: biosimilar developers targeting pembrolizumab itself, and branded competitors already on the market

For people with diabetes taking insulin or sulfonylureas, starting a GLP-1 receptor agonist requires careful monitoring and potential dose adjustments of existing medications to prevent hypoglycaemia

Sublingual formulations : Designed for better absorption under the tongue