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The PDAC desmoplastic stroma is abundant in extracellular matrix (ECM) deposition, cancer-associated fibroblasts (CAFs), and disorganized endothelium, characterized by insufficient anti-tumoral response [11, 13, 14]

doi: 10.1016/j.pnpbp.2022.110580, 110 O'ConnorE

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With injections, the medication bypasses this process and is delivered more directly, which leads to: More predictable dosing Stronger appetite suppression More consistent results for many patients That does not mean pills do not work