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Its possible that retatrutide could receive conditional or accelerated access in certain countries before the U.S., especially in regions with regulatory pathways for breakthrough obesity therapies

10.1111/ene.13010 Eur J Neurol

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The included studies on exendin-4 exposure were all performed in mouse models ( In rat, mouse and rabbit models without systemic inflammation, the other GLP1-receptor agonists (except exendin-4), dose dependently caused reduced fetal weight and/or growth, retardation of ossification, irregular ossification, and/or skeletal variants such as wavy ribs ( Table 1 )