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Ipamorelin is a growth hormone secretagogue that activates the ghrelin receptor (GHS-R1a) a completely separate pathway that is synergistic with GHRH receptor activation

doi: 10.3390/jpm12030454 128 CaniPDAmarJIglesiasMAPoggiMKnaufCBastelicaDet al

The ROS generated from aerobic respiration caused a cumulative oxidative damage in macromolecules, including lipids, DNA, and proteins, which subsequently lead to cells death (Scheibye-Knudsen et al., 2015), and affect the healthspan of numerous principal organ systems (Dai et al., 2014)