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7 Despite the substantial amount of data indicating an association between decreased hippocampal BDNF levels and depression, and the critical function of BDNF in antidepressant action, there is no direct evidence that localized reduction in BDNF protein levels can actually affect behaviors associated with depression, or perhaps reduced BDNF levels is merely a side effect of stress and depression

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An empty stomach generally allows for better absorption of certain nutrients because there is no competition from food