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For instance, depletion of mGSH results in Trx2 oxidation (Zhang et al., 2007), while hypercholesterolemic pigs with selective depletion of mGSH in heart mitochondria, exhibit decreased levels of the mitochondria-specific antioxidant enzymes such as SOD2, Trx2, and Prx3 (McCommis et al., 2011)

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Studies in cardiac injury models demonstrated reduced fibrosis and inflammation following TB-500 administration

A specific concern is cannabis hyperemesis syndrome, characterized by persistent nausea, vomiting, and abdominal pain, which can complicate diabetes management and lead to dehydration or electrolyte imbalances [24]