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The caloric deficit from Retatrutide already provides significant fat loss stimulus

Since effective LDL-C reduction is the most important method to improve the prognosis in HoFH, intensive treatment should be carried out, involving all available interventions, i.e., high doses of potent statins, ezetimibe, PCSK9 inhibitors, and LDL apheresis [265, 284]

Step 6 Long-Term Protocol: Retatrutide is a treatment for chronic metabolic disease not a short-term course