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They have also been shown to reduce the rates of major adverse cardiovascular events, comprising non-fatal myocardial infarction, non-fatal stroke, and cardiovascular death, in patients with type 2 diabetes mellitus

As the landscape of cardiometabolic therapeutics evolves rapidly, real-world evidence may serve as a critical tool to generate comparative insights beyond trials that is essential for clinical decision-making and regulatory evaluation

The World Health Organization International Clinical Trials Registry Platform (ICTRP) and the ClinicalTrials.gov registry were also reviewed to find unpublished or ongoing trials

Diabetic Agents, From Metformin to SGLT2 Inhibitors and GLP1 Receptor Agonists: JACC Focus Seminar