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The JM region contains an NPEY motif that, after being phosphorylated, serves as a docking site for Shc and the insulin receptor substrates (IRS), whose recruitment signifies the start of the downstream signaling process

An MHRA spokesperson said: Alongside increased usage, we are seeing an upturn in the number of Yellow Card reports mentioning GLP-1 medicines and acute pancreatitis. Due to the impact of this serious disease on patients, the MHRA said it wanted to understand whether there were any genetic factors at play

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Moreover, a greater number of people in the alpha-lipoic acid group experienced nausea, protein in the urine, and poor kidney function than those given placebo [19]