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The initial laboratory evaluation should include a complete blood count, plasma glucose, electrolytes (including calculated anion gap), blood urea nitrogen (BUN), creatinine, ketones (serum/urine), osmolality, and venous or arterial blood pH, and urinalysis [811]

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Mechanistically, ER transcriptionally upregulated the expression of SLC7A11 and SLC3A2, two subunits of the system x c , which is one key inhibitory regulator of ferroptosis