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By leveraging their immune characteristics, genetic stability, and behavioral traits, BALB/c mice provide a versatile and powerful tool for AD research

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The homologous cytochrome CYP2A6 of humans in Cyp2a5 mice is expressed in several liver diseases by the induction of toxic chemicals [77], where the levels of mRNA and Cyp2a5, on comparison between knockout NRF-2/ and wild-type mice, proved the increase of NRF-2 and Cyp2a5 in wild-type mice, as well as their interaction by co-immunoprecipitation Cyp controlled by NRF-2 [77]

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