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In catabolic conditions, the PLC, PKC, and MAPK/ERK signaling cascades play an important role in activating HSL and releasing lipids for energy production and as outlined, both GH and IGF can activate these pathways (134)

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GLP-1 receptor agonists and related incretin-based peptides reduce HbA1c, body weight and certain cardiovascular risk markers in appropriate patients, especially when combined with nutrition and activity interventions