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Different combinations or even larger cocktails of agonists and/or antagonists may turn out to be even more effective going forward
In our overall analysis of studies reporting outcomes at different time frames, we included data with the longest follow-up periods
Current consensus is that GLP-1 treatment benefits outweigh the risk of EWDR: the drugs reduce the risk of further microvascular damage from poor glycemic control and reduce the chance of death from cardiovascular disease, while the impact on DR is short-lived and can be treated
In summary, convergent evidence from both preclinical and clinical research underscores the capacity of GLP-1RAs to interact with neural circuits that govern reinforcement and motivation, networks that are also targeted by drugs of abuse
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