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Research emphasizes the importance of the endocannabinoid system (ECS) in neurotrophic factor signaling during fetal CNS development, regulating synaptogenesis, axon growth, neuronal cell fate, migration, and proliferation, as well as neuroprotection mediated by CB1R and BDNF, preventing neuronal death, and the ECSs influence on dopaminergic systems (primarily through D2 receptors), GABAergic, and glutamatergic systems (163)

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For a 1-year lag period the HR was 0.83 (95% CI, 0.56-1.22), and for a 2-year lag period the HR was 0.90 (95% CI, 0.58-1.38)