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In addition to supporting the delivery of growth factors and nutrients to RGCs, glial cells also play a primary role in removing excess glutamate from the extracellular space to prevent RGC damage associated with glutamate excitotoxicity [91, 98, 99]

NO is a crucial physiological signaling molecule in a diverse array of organ systems, and has important anti-inflammation effects, thereby exerting effect upon cardiovascular function, including vasodilation and endothelium protection