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Future studies are called for to define liver-specific metformin effects and identify cirrhotic patients that would benefit from metformin use

Within the framework of clinical trial design, predictive modeling based on imaging, body fluid biomarkers, genetics, and digital signals can enhance participant selection, identify fast progressors or treatment-responsive subgroups, and enable real-time adaptive modifications to trial parameters

However, the current research on the relationship between GPx2 and breast cancer is limited and there are still many gaps in the research regarding its regulatory mechanisms

Park EY, Shimura N, Konishi T, Sauchi Y, Wada S, Aoi W, et al