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SPS, single prolonged stress

The P c ir value represents the predicted effective human jejunal permeability of the molecule (Table 10), The predicted P e n- value for dihexa (1.78) is intermediate between the predicted P e ff values for enalapril (1.25) and piroxicam (2.14), two orally bioavailable drugs, dihexa was also predicted to be 22.59 percent unbound to plasma proteins in circulation, thus making it available for distribution into the tissues

The treatment effect was then evaluated using Cox proportional hazard regression, with cage assignment included as a random effect and batch as a covariate, using statistical software R (version 3.4.1) with package coxme