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An additional mechanism by which bile acid induction of FXR reduces hepatic accumulation of toxic bile acids is by activation of the ABCB11 gene, which encodes the canalicular bile salt export pump (BSEP), allowing a higher rate of bile salt export from hepatocytes

10.1016/j.matbio.2019.12.003 60 YanJ.ZhengY.MinZ.NingQ.LuS

In the same study, the human colon carcinoma cell line HCT116 was revealed to be less sensitive to the bleomycin treatment, in line with the very low expression of CT2 and with the metabolism based on glycolysis rather than on FAO (Aouida et al., 2010)