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Disruption in the pathways of -cell formation or an increased rate of -cell death can result in a decrease in -cell mass [1]

While mild nausea and early satiety are expected and generally manageable, patients should seek immediate medical attention for severe or persistent vomiting, severe abdominal pain (especially if radiating to the back), right upper quadrant pain with fever or jaundice, or inability to maintain adequate hydration

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Tirzepatide, characterized by its ability to selectively bind and activate receptors for the intestinal hormones GIP and GLP-1, has been tested in numerous clinical studies and is already currently authorized in several countries for the treatment of type 2 diabetes and obesity