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A subgroup analysis by weight reduction iced the case for proportionate benefit of symptom relief and less inflammation (by biomarkers) as a function of weight loss These are striking results for people with HFpEf given the only other drugs that have thus far shown benefit are the sodium-glucose cotransporter 2 (SGLT2) inhibitors

Comparison of treatments was done on a within-subject level (each mouse was its own control) and at least 1 week elapsed between each testing condition (drug or control treatment)

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The endothelium lines blood vessels and plays a critical role in maintaining vascular health