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Following FOXO4 displacement, the released p53 undergoes nuclear export and mitochondrial translocation, activating the intrinsic apoptosis pathway via BAX upregulation and BCL-2 downregulation, culminating in caspase-3 cleavage and apoptotic cell death
Before health systems can fully benefit from advanced clinical decision intelligence, they need the data infrastructure, workflow integration, governance, and workforce adoption required to make those tools operationally useful
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