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GLP-1 therapy 101 How GLP-1 therapy for weight loss works GLP-1 therapy involves using glucagon-like peptide-1 receptor agonists to mimic natural hormones that regulate appetite and insulin secretion

Here's the probability that a preclinical study even makes it to the phases

These medications also show cardiovascular and renal benefits, such as reducing blood pressure, improving endothelial function, and lowering the risk of cardiovascular events like myocardial infarction and stroke [6][16]