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The latter activity, we suggest, is likely the result of multiple effects such as decreased lysosomal enzyme activity due to the pH increase or by direct enzymatic inhibition following lysosomal accumulation
cardiovascular death, nonfatal myocardial infarct, nonfatal stroke) for the GLP-1RA albiglutide, efpeglenatide, dulaglutide, liraglutide, and semaglutide ( The GLP-1RA liraglutide has also been approved for the treatment of obesity at a higher standard dose (3 mg once daily) compared to the standard dose used for T2D treatment (1.2 mg once daily) due to the results of the SCALE study program (37, 38)
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