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Under the rich nutrient state, mTORC1 binds to the ULK1 complex and inhibits the initiation of autophagy through inhibitory phosphorylation of ULK1 at Ser-757 (Kim et al., 2011

The study authors did a commendable job bolstering the case that this was a good apples to apples comparison by first comparing only people getting new diabetes medication, then statistically controlling for a whole range of other sociodemographic factors (age, education, race/ethnicity, area-level income) and MANY baseline health characteristics and health behaviors

Answer: The most reported benefits are improved detoxification, brighter and more even skin tone, better energy and recovery, stronger immune resilience, and antioxidant support for overall cellular health