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Analysis of the PRM data was done in Skyline software and chromatographic peaks were manually validated in a similar fashion as the SRM data which led to keep 4 GPX3 peptides and 2 SEPP1 peptides for quantification

The recommended dosage will depend on the patients condition and the medical professionals discretion for optimal outcomes

The comparability of patient characteristics between two study groups was achieved by the three-step matching on (1) the index date, (2) prior exposure to GLAs in the year before the index date, and (3) patient demographic and clinical characteristics (e.g., diabetes severity, comorbidities, co-medications for cardiovascular diseases [CVDs]) using the propensity score matching approach [6]

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