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Common physical withdrawal symptoms include: Muscle aches, joint pain (particularly in the back and limbs) flu-like symptoms, including a runny nose, excessive tearing, and temperature regulation problems, such as hot flashes and chills Gastrointestinal distress presents as nausea, vomiting, diarrhea, and abdominal cramping Sleep disturbances, difficulty falling asleep, frequent nighttime awakening, and nonrestorative sleep patterns

2025;136(4):e70021

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