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Statements Author contributions XL: Software, Conceptualization, Investigation, Writing original draft, Writing review and editing

Non-Motor Symptoms Dopamine is involved in a number of functions beyond control of movement, so loss of dopaminergic neurons (and other neurons in late-stage Parkinson's) can cause several non-motor symptoms as well

It has been shown to benefit those with joint degeneration, a common cause of pain in the knees, back, hands and hips

74 Progressively, chronic exposure to high glucose and lipids affects the survival of islet cells, and the loss of mass gradually exacerbates with the prolongation of T2D and becomes the main factor involved in insufficient secretion of insulin