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Follow these steps for optimal use: Wet the skin with clean, lukewarm water before application Gently massage the soap onto the face or body until a light lather forms Leave the lather on the skin for 20 to 30 seconds to allow contact with the skin surface Rinse thoroughly with water and pat the skin dry using a soft towel Important usage tip: After rinsing, do not rub the skin aggressively with a towel

10.3389/fendo.2020.00025 Front Endocrinol

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However, orforglipron patients lost around twice as much, at between 4.7% and 7.9% of their weight